Doctors may see the loss of collagen in the skin as an indication that the person is experiencing a similar reduction in bone health. Symptoms The symptoms of senile purpura most commonly occur on the exposed parts of the skin, such as the arms, hands, or top of the head. Older adults who bleed very easily tend to experience purpura more often.
Surveillance after treatment Hodgkin lymphoma patients in first remission: Novel therapy for Hodgkin lymphoma. Brentuximab vedotin, which was approved inis already shifting the treatment paradigm of HL. Management of early-stage Hodgkin lymphoma: In an editorial, Dr. Longo writes that the escalated BEACOPP regimen "has not gained traction outside of Germany for several reasons," which include substantially greater acute haematologic toxicity and a much higher rate of secondary acute leukemia and myelodysplasia than ABDV.
It should be noted that imaging with PET after two cycles of therapy appears to reliably predict who will have disease progression - which could potentially help to avoid "over treating the majority of patients.
This study is evaluating risk-adapted treatment following 2 cycles of ABVD. Some patients may wish to avoid the risks associated with BEACOPP cited in the Medscape coverage of this report, however it seems to be important for patients to fully consider any proven survival advantage -- which accounts for all risk factors known and unknown.
Longo seems to be addressed by the improvement in overall survival - assuming that the meta analysis accounts for these outcomes as well. I think the controversy shows the importance of shared decision-making.
Assuming that the more aggressive approach is better in terms of survival, the well-informed patient might still choose the less effective but lower toxic protocol It will be important to know the magnitude of the improvement in survival for BEACOPP and how do the treatment compare in terms of toxicities short and long term.
This issue remains to be resolved in prospective trials. J Natl Compr Canc Netw Targeted therapy in relapsed classical Hodgkin lymphoma.
Loss of utility of bone marrow biopsy as a staging evaluation for Hodgkin lymphoma in the PET era: This report appears to be good news for patients - reducing the need to have worrisome procedures to stage at diagnosis and monitor for response to treatment.
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This is an intermediate level course. After taking this course, mental health professionals will be able to: List and discuss four medical causes of mental disorders.
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This is an intermediate level course. After taking this course, mental health professionals will be able to: List and discuss four medical causes of mental disorders. Abstract. The knee is a common site for bone tumors, whether clinically painful or not. Conventional radiology has been established as the first line of investigation in patients with knee pain and can reveal lesions that often generate questions not only for the generalist physician but also for the radiologist or general orthopedist.